Mechanism of action of tacrolimus tacrolimus ointment is a topical calcineurin inhibitor tci and was the first of this class of topical preparations to be developed particularly for the treatment of ad23 tacrolimus is a macrolide lactone with unique immunomodulatory properties and was originally isolated in japan in 1980 from the fungus like bacterium streptomyces tsukubaensis. Tacrolimus ointment protopicr fujisawa is an effective agent in a class of topical immunomodulators it has been shown to be safe and effective in adults and children with atopic dermatitis in short and long term treatments. Tacrolimus ointment is the first of a new class of non steroidal topical immunomodulators indicated for the treatment of atopic dermatitis topical tacrolimus has been subject to an extensive . Tacrolimus ointment is the first in the new class of steroid free topical immunomodulators tims and as such represents the first true breakthrough since the introduction of topical steroids more than 50 years ago for the treatment of t cell mediated inflammatory skin diseases such as atopic dermatitis what is topical immunomodulator. Detailed tacrolimus topical dosage information for adults and children long term use of topical calcineurin inhibitors in any age group should be avoided and application limited to areas of atopic dermatitis the 01 ointment is not indicated for use in children less than 16 years of age tacrolimus 01 ointment tacrolimus topical
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